The Breakthrough Challenge
We raise funds to support breakthroughs in cancer research at Penn Medicine's Abramson Cancer Center (ACC). Founded in 2013, the Breakthrough Challenge unites patients, researchers, their families, and friends for a scenic and inspiring bike ride through Eastern PA's beautiful Oley Valley. To date, the Breakthrough Challenge has donated $2,825,000 to the ACC, funding 63 research projects. 100% of all participant-raised dollars are donated directly to cancer research.
View Breakthrough Challenge 2025 Images
Our 2025 Fundraising Goal
Thank You to our donors, sponsors, volunteers, and riders!
Giving Tuesday 2025
This Giving Tuesday, December 2nd, 2025, the Breakthrough Challenge invites you to join us in our mission of eradicating cancer.
Every dollar contributed goes directly to paradigm-shifting cancer research at Penn Medicine's Abramson Cancer Center.
Thank you for helping us fuel hope, innovation, and progress!
Breakthroughs in Action
Thank You To Our Fundraisers!
Join Us to Make a Difference!
