In Person Ride: Sunday 14, 2025
Location: Daniel Boone Homestead
The Breakthrough Challenge was founded in 2013. Our goal is to raise funds supporting breakthroughs in cancer research at Penn Medicine's Abramson Cancer Center by uniting for a scenic and inspiring bike ride through Eastern PA's beautiful Oley Valley.
There are three ride options based on length of miles. We also host virtual events if you wish to participate in running, spinning, walking and biking at any location. Please click on the ride option below and sign-up.
*Please be prepared to have wheels on the ground and ready to ride by the designated start time.
If you own an Epi Pen, please do not forget to bring it with you.
Event Registration (Click Below)
12 Mile Ride
12 Mile Ride
$75
$50
10:00AM EDT
- 1:30PM EDT
12 mile: September 14, 2025 arrive by 10:30 am
25 Mile Ride
25 Mile Ride
$75
$50
9:30AM EDT
- 1:30PM EDT
25 mile: September 14, 2025 arrive by 10:00 am
50 Mile Ride
Virtual Events
Please note, if you are looking to register as a volunteer, please use the button below:
Venue Details
ROUTES
Post Ride Lunch 11:15 am to 2:00 pm
PARKING WILL BE AVAILABLE ON SITE
Please note there is a 10 mph vehicle speed limit within Daniel Boone Homestead.
We will also have complimentary soft drinks and beer.
A DJ will keep the action going with music and announcements.
